ritlecitinib will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Ritlecitinib inhibits CYP3A4 substrates; coadministration improves AUC and peak plasma concentration delicate substrates, which can maximize risk of adverse reactions.Keep track of Closely (1)enasidenib wi